The second channel will not be used, it will just control the central heating. I have Nest Gen 3 and rather disappointed with it. Although told it would link to TRV's it does not.
Worcester Bosch only allow their own ebus thermostats to be used, so can't use the OpenTherm option, so you really want a thermostat which only switches off when all rooms are satisfied, every time an on/off thermostat switches off and on again, the boiler starts again from scratch setting the output to match demand, so is not running as efficiently until it has set how much it needs to modulate, the whole idea is the room temperatures are set with the TRV, as each TRV closes more water is forced though those still open, and then the by-pass valve starts to open allowing hot water direct back to boiler, the boiler uses the return water temperature to set how much it needs to modulate (turn down) so it is able to gain the latent heat from the flue gases. It also means a smooth temperature, with little or no hysteresis.
When the boiler is turning on/off all the time, the TRV can't get the temperature so smooth, my oil boiler can't modulate so turns on/off all the time, so looking at the report from the TRV head we get this
as the boiler is switching on/off, with gas it should be smooth.
Most the better thermostat connect to the TRV so the TRV heads tell them what to do, Evohome, Wiser, Hive etc. You need to select TRV heads that work with the wall thermostat for critical rooms, but most rooms can use cheaper options, I used eQ-3 heads at £15 each in 2019 when I got them, also Terrier i30 heads are cheap, the head that gives the report shown is TP-Link (Kasa) and needs a hub.
Also found the geofencing on Nest useless, you can set eco and comfort temperatures but not the distance from home when the heating raises to the higher temperature again. And the learning bit, think it was a mischievous little boy when you see the settings it selected.