150mm is a pretty big hole - are you sure that your drill is up to it? This is the sort of job where you can all too easily burn out a combi drill by overheating the motor or cooking the battery. So, if you have a cordless drill it will ideally need to be top of the range (i.e. one with a metal chuck, metal gearbox housing and metal gears inside) and you will need to have an extra long side handle fitted because when (probably not if) the holesaw digs in and stalls it will kick back like a mule, potentially wrenching the tool out of your hands. I think almost everyone I know (tradesmen) has had this happen to them more than a few times over the years. For a corded tool doing the same job you'll need a heavy drill with a side handle. In both cases you need to keep the speed down to no more than 150rpm, ideally a lot less (more to reduce injury risk too yourself). One problem is that some insulation, e.g. mineral wool types, have a tendency to wrap themselves around the teeth of the hole saw, clog it and stall the tool. Similarly with some msterials like MDF and damp wood you will need to removecthe saw from the cut regularly to clean the (clogged) teeth
TBH stitch drilling, whilst not as neat, is a heck of a lot safer with these big diameter holes