remove any loose and naff tiles. but what i would be inclined to do is treat the tiles aswell, you can do this by getting a 4/1 mix of pva and water dip your brush in the pva then whilst it is loaded dip your brush in sand (any sand will suffice) then paint the tiled wall. do this the day before you dot 'n' dab and you won't get a problem. the wall when dry will feel like sandpaper to the touch, an ideal key.
dj.