Consider building an insulated stud wall to make your heated area smaller. A desk plus filing area may be as small as 2m x 2m.
Hmmm? At about 20p per kWh you must be using 25 kWh per day, about 2.5kW average for a ten hour working day. That's a lot of heat to lose from a 'well insulated' building.
Have you considered a 4kW air source heat pump? For 1 kW of electrical power you can enjoy 'about' 3kW of heat in winter, and 4 to 5 kW in spring and autumn, so you'll spend about £2 per day to run it, using your figures. Because they blow warm air the room will appear to warm up quickly, and they can also be used to give comfort cooling in the summer. Capital costs are coming down, though a decent branded ASHP will cost up to £1500. If you're fitting it yourself you MAY need a certified f-gas fitter to commission it, though if you buy a fitted package you'll pay more but may be able to get funding via the Green Homes Scheme announced last summer.
ASHPs are about as noisy as a large 'fridge, and that may be important to you, but certainly no intrusive to normal conversation.